"V体育官网" Immune response and inflammatory pathway of ulcerative colitis
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Nitima Tatiya-aphiradee (VSports)
Abstract
Ulcerative colitis (UC) is an idiopathic relapsing inflammatory disease. Although the etiology of UC remains unclear, it could be characterized by inflammation of the intestinal mucosa, starting from the rectum and potentially involving the entire colon. The immune response and inflammatory pathway of UC have shown that tissue damage is driven by dynamic and complexes of cells and cytokines VSports app下载. Various types of cells, including antigen-presenting cells (dendritic cells and macrophages), T helper cells, regulatory T cells, and natural killer T cells, play a crucial role in UC pathogenesis by regulation, suppression, and maintenance of inflammation. Moreover, cytokine networks become an important part due to their signaling function, which is indispensable for cell communication. Pro-inflammatory cytokines [tumor necrosis factor-α, interleukin (IL)-1, IL-6, IL-9, IL-13, and IL-33] play significant roles in upregulation, while anti-inflammatory cytokines (transforming growth factor-β, IL-10, and IL-37) play significant roles in downregulation of disease progression. The pathogenesis of UC consists of immuno-inflammatory pathways related to the multiple components of the intestine, including the epithelial barrier, commensal microflora, antigen recognition, dysregulation of immunological responses, leukocyte recruitment, and genetic factors. The understanding of immuno-inflammatory pathways of UC might lead to the development of a specific therapy and/or a novel treatment that could be more efficient.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
VSports注册入口 - References
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Immune response and inflammatory pathway of ulcerative colitis
- Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer
- Behavior and Neuroprotection
- Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents (VSports)
- Reproduction
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- Cardiovascular-Pulmonary Interactions
- Local inhibition of carbonic anhydrase does not decrease sweat rate
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- Oxidative Stress
- "V体育ios版" Zataria multiflora extract and carvacrol affect cardiotoxicity induced by Adriamycin in rat
- Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats
- Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats
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V体育2025版 - Articles in the same Issue
- Frontmatter
- Reviews
- Immune response and inflammatory pathway of ulcerative colitis
- Current insights and future perspectives of hypoxia-inducible factor-targeted therapy in cancer
- Behavior and Neuroprotection
- Effect of caffeine on alcohol consumption and alcohol-induced conditioned place preference in rodents (V体育官网)
- Reproduction
- Pubertal anabolic androgenic steroid exposure in male rats affects levels of gonadal steroids, mating frequency, and pregnancy outcome
- Dynamics of inflammatory reaction and oxidative stress across maternal serum, placenta and amniotic fluid in laboratory rats and the role played by genistein aglycone
- Cardiovascular-Pulmonary Interactions
- Local inhibition of carbonic anhydrase does not decrease sweat rate
- The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats
- Correlation between the blood level of irisin and the severity of acute myocardial infarction in exercise-trained rats
- Oxidative Stress
- Zataria multiflora extract and carvacrol affect cardiotoxicity induced by Adriamycin in rat (VSports在线直播)
- Attenuation of oxidative stress and hepatic damage by white butterfly (Clerodendrum volubile) leaves in streptozotocin-induced diabetes in rats
- Proline supplementation mitigates the early stage of liver injury in bile duct ligated rats
- Pravastatin attenuates testicular damage induced by doxorubicin – a stereological and histopatological study (V体育安卓版)
- Metabolism
- Re-establishing normal diet following high fat-diet-induced obesity reverses the altered salivary composition in Wistar rats
- Phytotherapy
- In vivo analgesic effect of different extracts of Hopea odorata leaves in mice and in silico molecular docking and ADME/T property analysis of some isolated compounds from this plant
- Hepatoprotective activity of V体育平台登录 - Tamarindus indica Linn stem bark ethanolic extract against hepatic damage induced by co-administration of antitubercular drugs isoniazid and rifampicin in Sprague Dawley rats
- Case Report
- Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis
