Background: Some studies have reported that Toll-like receptor 4 (TLR4) D299G and T399I polymorphisms are associated with increased Crohn's disease (CD) and ulcerative colitis (UC) risk in the Caucasian population. However, the results have been inconsistent VSports手机版. .

Methods: A systemic review of the published data (16 studies with 8,387 cases and 7,013 controls for D299G; 8 studies with 3,881 cases and 1,861 controls for T399I) was undertaken and a meta-analysis was performed to test whether TLR4 D299G and T399I polymorphisms were associated with CD or UC susceptibility and whether 299Gly carriage was associated with phenotypes of CD patients V体育安卓版. .

Results: The TLR4 299Gly allele showed a significant association with CD and UC in the Caucasian population (OR 1. 29, 95% CI 1. 08-1. 54, and OR 1. 28, 95% CI 1. 08-1. 51, respectively). Similar association was detected between the T399I polymorphism and susceptibility to CD and UC (OR 1. 37, 95% CI 1. 12-1. 68, and OR 1. 46, 95% CI 1. 13-1 V体育ios版. 88, respectively). However, no significant association was identified between CD phenotypes and 299Gly carriage. .

Conclusion: The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians VSports最新版本. Additional well-powered studies of the association between TLR4 variants and UC are needed. .