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. 1999 Feb 12;283(5404):1001-4.
doi: 10.1126/science.283.5404.1001.

VSports最新版本 - Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

R E Johnson  1 , S Prakash, L Prakash
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Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

"VSports手机版" R E Johnson et al. Science. .

Abstract

The RAD30 gene of the yeast Saccharomyces cerevisiae is required for the error-free postreplicational repair of DNA that has been damaged by ultraviolet irradiation. Here, RAD30 is shown to encode a DNA polymerase that can replicate efficiently past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally blocks DNA polymerases. When incubated in vitro with all four nucleotides, Rad30 incorporates two adenines opposite the thymine-thymine dimer. Rad30 is the seventh eukaryotic DNA polymerase to be described and hence is named DNA polymerase eta VSports手机版. .

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