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Comparative Study
. 2018 Aug;67(8):1512-1523.
doi: 10.2337/db17-1488. Epub 2018 May 23.

The Transplantation of ω3 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Célia Bidu  1   2   3 , Quentin Escoula  1   2   3 , Sandrine Bellenger  1   2   3 , Aymé Spor  4 , Maxime Galan  5 , Audrey Geissler  6 , André Bouchot  6 , Dominique Dardevet  7   8 , Béatrice Morio  9 , Patrice D Cani  10 , Laurent Lagrost  2   3   11 , Michel Narce  12   2   3 , Jérôme Bellenger  12   2   3
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Comparative Study

The Transplantation of ω3 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Célia Bidu et al. Diabetes. 2018 Aug.

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Abstract

Altering the gut microbiome may be beneficial to the host and recently arose as a promising strategy to manage obesity. Here, we investigated the relative contribution of ω3 polyunsaturated fatty acid (PUFA)-mediated alterations in the microbiota to metabolic parameter changes in mice. Four groups were compared: male fat-1 transgenic mice (with constitutive production of ω3 PUFAs) and male wild-type (WT) littermates fed an obesogenic (high fat/high sucrose [HFHS]) or a control diet. Unlike WT mice, HFHS-fed fat-1 mice were protected against obesity, glucose intolerance, and hepatic steatosis. Unlike WT mice, fat-1 mice maintained a normal barrier function, resulting in a significantly lower metabolic endotoxemia. The fat-1 mice displayed greater phylogenic diversity in the cecum, and fecal microbiota transplantation from fat-1 to WT mice was able to reverse weight gain and to normalize glucose tolerance and intestinal permeability VSports手机版. We concluded that the ω3 PUFA-mediated alteration of gut microbiota contributed to the prevention of metabolic syndrome in fat-1 mice. It occurred independently of changes in the PUFA content of host tissues and may represent a promising strategy to prevent metabolic disease and preserve a lean phenotype. .

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