The Transplantation of ω3 PUFA–Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Pal1, Al‐Shaer2, Guesdon3 et al. 2019Preprint111241Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…EPA ethyl ester supplementation does not modify the composition of the gut microbiome relative to mice on a high fat diet. Previous studies suggest that mixtures of EPA/DHA promote specific compositional changes in the microbiome in a manner that supports lower systemic inflammation associated with insulin resistance [29][30][31] . Therefore, we conducted a microbiome study with control, high fat, and high fat + EPA ethyl ester diets. …”Section: Resultsmentioningconfidence: 97%“…More importantly, EPA did not improve changes in the gut microbiota induced by a high fat diet. Some studies show that n-3 PUFA-enriched fish oils or fat-1 transgenic mice remodel the gut microbiome to lower the abundance of Gram negative bacteria [29][30][31] . EPA ethyl esters are clearly remodeling several lipid pools (as the metabolomics data show), which may in turn influence metabolites generated by the gut microbiome. …”Section: Discussionmentioningconfidence: 99%“…Subsequently, we investigated if EPA ethyl esters remodel the composition of the gut microbiome VSports app下载. The rationale for microbiome 5 studies was driven by evidence that EPA/DHA-enriched fish oils change the composition of gut bacteria to lower systemic inflammation and decrease endotoxemia, a driver of metabolic complications such as insulin resistance [29][30][31] . Parallel hypothesis-generating metabolomic experiments were conducted to identify targets of EPA ethyl esters. …”Section: Introductionmentioningconfidence: 99%See 1 more Smart Citation

V体育官网入口 - Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

Pal1, Al‐Shaer2, Guesdon3 et al. 2019Preprint111241Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…[ 23 ] Fat‐1 transgenic mice that endogenously convert n‐6 to n‐3 PUFAs had higher levels of Tenericutes, Akkermansia , and S24‐7 but less abundant Ruminococcus compared with wild‐type mice. [ 41 ] Here, we comprehensively assessed the individual effect of dietary n‐3 PUFAs on the microbiome in male and female DIO mice and revealed the similarities and differences between DHA and EPA. Notably, we found that EPA and DHA consistently favored the growth of Lactobacillus which has been evidenced to improve gut integrity, endotoxemia, and inflammation [ 42,43 ] as well as SCFA‐producing species from Lachnospiraceae [ 44 ] in both male and female DIO mice. …”Section: Discussionmentioningconfidence: 99%

Eicosapentaenoic and Docosahexaenoic Acids Differentially Alter Gut Microbiome and Reverse High‐Fat Diet–Induced Insulin Resistance

Zhuang1, Zhang2, Shou3 et al. 2020Molecular Nutrition Food Res823590Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These metabolic disturbances were accompanied by reductions in phylogenetic diversity in the saturated fat-fed mice, and receipt of transplanted microbiota from mice fed fish oil abrogated saturated fat-induced inflammation (31). Furthermore, transgenic mice that constitutively produce w3 polyunsaturated fatty acids possess a microbiome with enhanced phylogenetic diversity that offers protection against the metabolic consequences of a high-saturated-fat, high-sugar diet (32). …”Section: Dietary Fatsmentioningconfidence: 99%

The gut microbiota at the intersection of diet and human health

Gentile1, Weir2 2018Science92635810Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.