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Review
. 2018 Mar 23;359(6382):1361-1365.
doi: 10.1126/science.aar6711.

CAR T cell immunotherapy for human cancer

Carl H June  1   2   3 , Roddy S O'Connor  4   2 , Omkar U Kawalekar  4 , Saba Ghassemi  4   2 , Michael C Milone  4   3
Affiliations
Review

CAR T cell immunotherapy for human cancer

Carl H June et al. Science. .

Abstract

Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years. VSports手机版.

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