CAR T cell immunotherapy for human cancer (V体育2025版)

CAR-T cells : indications actuelles en pédiatrie et perspectives de développement

Dourthe1, Yakouben2, Chaillou3 et al. 2018Bulletin du Cancer2000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Il reste encore de nombreux obstacles à franchir pour l'appliquer avec succès dans cette indication [43]. …”Section: Resultsunclassified“…Le microenvironnement tumoral constitué de lymphocytes T régulateurs, cellules myéloïdes immunosuppressives, checkpoints immuns peut diminuer l'efficacité des CAR T cells. Des essais cliniques sont actuellement menés évaluant l'intérêt de combiner des anticorps bloquant PD1/PD-L1 à des CAR T cells GD2 dans les neuroblastomes [43]. Dans les tumeurs du système nerveux central, le rôle de la barrière hématoencéphalique ainsi que la circulation des lymphocytes T dans le SNC sont des freins éventuels à l'accessibilité des CAR au sein de la tumeur [32]. …”Section: Amélioration De L'efficacité Dans Les Tumeurs Solidesunclassified

CAR-T cells : indications actuelles en pédiatrie et perspectives de développement

Dourthe1, Yakouben2, Chaillou3 et al. 2018Bulletin du Cancer2000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Two key elements of CAR-T composition need to be considered: (1) the structure of the CAR construct itself, and (2) the cellular composition of the infused product. (1) The structure of the CAR transgene has evolved from a "first-generation" structure, which expressed the CD3-z signaling domain, to "second-generation" CARs, in which one of many possible costimulatory signals (the 2 most common being CD28 and 41BB signals) were added to CD3-z, to "third-generation" CARs, which contain 2 costimulatory signals in tandem (CAR construct structure reviewed in June et al 129 ). Although the identity of the costimulatory domains have gained the most attention of late, there are multiple other considerations in engineering an optimal CAR construct, and a comprehensive discussion of these is beyond the scope of this review. …”Section: Cell Manufacturing and Patient Selectionmentioningconfidence: 99%

Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis

Kean1 2018Blood11080Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…They are composed of an antigen recognition derived from an antibody and the signaling domain of the TCR, combining the specificity of an antibody with the cytotoxic and memory functions of T cells, targeting in a non-MHC-restricted manner surface antigens [95]. …”Section: Chimeric Antigen Receptor T Cell Therapymentioningconfidence: 99%

T lymphocytes as therapeutic arsenal for patients with hematological malignancies

Montoro1, Piñana2, Sanz3 et al. 2018Current Opinion in Oncology4030Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim VSports app下载. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.