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. 2018 Jun;37(25):3356-3368.
doi: 10.1038/s41388-018-0224-1. Epub 2018 Mar 21.

OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

Honghong Zhou  1   2 , Yongshuo Liu  1 , Rui Zhu  1 , Fang Ding  1 , Xiufeng Cao  3 , Dongxin Lin  1   2 , Zhihua Liu  4
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OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

Honghong Zhou et al. Oncogene. 2018 Jun.

Abstract (V体育ios版)

Snail is a key regulator of epithelial-mesenchymal transition (EMT) and plays an important role in tumor progression and metastasis. Snail is rapidly degraded in the cells and its protein level is critically controlled. Although several E3 ligases regulating Snail degradation have been defined, the deubiquitinases (DUBs) responsible for Snail deubiquitination are less studied. We identified ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) as a DUB that stabilizes Snail through preventing its ubiquitination and proteasomal degradation. Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability VSports手机版. Moreover, OTUB1 is highly expressed in ESCC and higher expression of OTUB1 predicts poor prognosis. These findings suggest that OTUB1 is an essential regulator of Snail and plays a critical role in facilitating esophageal cancer progression. .

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References (VSports app下载)

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