OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability (VSports)

VSports. DUB3 (Liu et al, 2017;Wu et al, 2017), OTUB1 (Zhou et al, 2018), and USP27X (Lambies et al, 2019) have been identified as specific DUBs to stabilize Snail and play important roles in Snail-mediated tumor metastasis. In this study, we discover that USP37 directly binds Snail and markedly improves Snail protein stability through its deubiquitinase activity. …”Section: Introductionmentioningconfidence: 99%

USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination (VSports在线直播)

Cai1, Li2, Wang3 et al. 2020Front. Genet. 492380Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The balance between ubiquitination and deubiquitination is essential for maintaining essential biological processes in the cells. DUB3 (Liu et al, 2017;Wu et al, 2017), OTUB1 (Zhou et al, 2018), and USP27X (Lambies et al, 2019) have been identified as specific DUBs to stabilize Snail and play important roles in Snail-mediated tumor metastasis. In this study, we discover that USP37 directly binds Snail and markedly improves Snail protein stability through its deubiquitinase activity. …”Section: Introductionmentioningconfidence: 99%

USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

Cai1, Li2, Wang3 et al. 2020Front. Genet. 492380Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Recently, the role of OTUB1 on tumorigenesis has been the focus of functional research. Studies have shown that OTUB1 is closely related to the occurrence and development of hepatocellular carcinoma [15], colorectal cancer [16], esophageal squamous cell carcinoma [17], prostate cancer [18], gastric cancer [19] and lung cancer [20]. However, the regulation ability and underlying mechanism of OTUB1 on RCC have not been reported yet. …”Section: Introductionmentioningconfidence: 99%

OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma

Zhou1, Mai2, Zheng3 et al. 2020Cell Biosci322270Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…A group of DUBs, including OTUB1, DUB3, and USP3, are reported to stabilize Snail through preventing its ubiquitination and proteasomal degradation. OTUB1 promotes metastasis of esophageal squamous cell carcinoma through the stabilization of Snail [92]. DUB3 is found to be overexpressed in breast cancer, and depletion of DUB3 leads to Snail1 destabilization, which suppresses EMT, tumor invasiveness, and metastasis [90]. …”Section: Dubs and Metastasismentioningconfidence: 99%

"V体育官网" Role of Deubiquitinases in Human Cancers: Potential Targeted Therapy

Lai1, Chen2, Tse3 2020IJMS530390Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.