Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2017 Jan;13(1):49-58.
doi: 10.1016/j.nano.2016.08.018. Epub 2016 Aug 22.

Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture

Daniel Sepúlveda-Crespo  1 , José Luis Jiménez  2 , Rafael Gómez  3 , Francisco Javier De La Mata  3 , Pedro L Majano  4 , Ma Ángeles Muñoz-Fernández  5 , Pablo Gastaminza  6
Affiliations

Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture (VSports在线直播)

Daniel Sepúlveda-Crespo et al. Nanomedicine. 2017 Jan.

V体育官网 - Abstract

Hepatitis C virus (HCV) infection is a major biomedical problem worldwide. Although new direct antiviral agents (DAAs) have been developed for the treatment of chronic HCV infection, the potential emergence of resistant virus variants and the difficulties to implement their administration worldwide make the development of novel antiviral agents an urgent need. Moreover, no effective vaccine is available against HCV and transmission of the virus still occurs particularly when prophylactic measures are not taken. We used a cell-based system to screen a battery of polyanionic carbosilane dendrimers (PCDs) to identify compounds with antiviral activity against HCV and show that they inhibit effective virus adsorption of major HCV genotypes. Interestingly, one of the PCDs irreversibly destabilized infectious virions. This compound displays additive effect in combination with a clinically relevant DAA, sofosbuvir. Our results support further characterization of these molecules as nanotools for the control of hepatitis C virus spread. VSports手机版.

Keywords: Antiviral; Carbosilane dendrimer; Hepatitis C virus; Nanotechnology; Virucidal V体育安卓版. .

PubMed Disclaimer

LinkOut - more resources