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Review
. 2016 May 18;9(1):46.
doi: 10.1186/s13045-016-0276-z.

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Ke Zhao  1 , Qifa Liu  2
Affiliations
Review

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Ke Zhao et al. J Hematol Oncol. .

Abstract

Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response VSports手机版. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications. .

Keywords: Aplastic anemia; Engraftment failure; Graft-versus-host disease; Hematopoietic stem cell transplantation; Infection; Mesenchymal stromal cell; Relapse V体育安卓版. .

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Figures

Fig. 1
Fig. 1
Immunomodulatory effects of MSC. MSCs exert immunomodulatory effects mainly through central and peripheral immune compartments. MSCs modulate central immune compartments by repairing damaged thymus, promoting T-cells maturation, inducing the proliferation of natural Tregs, and differentiating to thymocytes. MSCs modulate peripheral immune compartments, including interacting with various immune cells and secreting various soluble mediators involved in different microenvironment. They suppress T cell and B cell proliferation, induce the generation and proliferation of Tregs and Bregs, inhibit differentiation of precursors into DCs, suppress DCs maturation, and influence the function of NK cells
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