The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

V体育ios版 - Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms

Redpath1, François2, Wong3 et al. 2017Blood Advances222280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Comparative in vitro studies of AMD3100 and KRH3955 revealed that KRH3955 exhibited a 100-fold lower IC 50 for CXCL12 binding, a stronger binding affinity, and a slower dissociation rate than did AMD3100. Moreover, in functional assays, KRH3955 was a more potent anti-HIV drug than was AMD3100. …”Section: Discussionmentioningconfidence: 96%“…This may be advantageous in the context of BMTs, in which MPCs are thought to improve engraftment of HPCs. [48][49][50] In addition, MPC mobilization may enhance tissue repair in the context of tissue injury, such as cardiovascular disease or a musculoskeletal injury. 45,49,[51][52][53] Acknowledgments KRH3955 was kindly donated by Kureha Corporation (Pharmaceuticals and Agrochemicals Division, Tokyo, Japan). …”Section: Discussionmentioningconfidence: 99%

Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms

Redpath1, François2, Wong3 et al. 2017Blood Advances222280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The same trends in IR were observed for all T cell subtypes, and of note, the CD3+CD8+ increase was steeper in the non-responders as compared to the responder group. This may reflect the persistence of an underlying disease mechanism in these patients [8] and call for new therapeutic protocols after transplant or use of adjuvant cellular therapy [3], such as mesenchymal stromal cells infusion, in order to damper the autoimmune and inflammatory response [17]. Delayed CD4+ T cell recovery was more pronounced in group A than in group B and was sustained at long-term VSports app下载. …”Section: Discussionmentioningconfidence: 99%

Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients (VSports注册入口)

Farge1, Arruda2, Brigant3 et al. 2017J Hematol Oncol703610Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Looking at the other functions of the MSCs, such as immune suppressive or modulatory effects, the therapeutic infusions of MSCs in experimental models of autoimmune encephalomyelitis showed reduced infiltration of T cells and macrophages followed by a reduction of demyelination in the brain and in the spinal cord [77][78][79][80]. Repeated administration of MSCs derived from a patient's mother completely cured a young patient suffering from severe grade IV graft-versus-host disease (GVHD); this is another observation, which clearly showed modulation of the properties of the infused MSCs paving a way for another dimension of the MSCs repairing property [21]. …”Section: Mechanism Behind the Mesenchymal Stem Cell Repairmentioningconfidence: 87%

Mesenchymal Stem Cells: A Future Option for Intervening Disease Management

Chandramoorthy1, Radhakrishnan2, Gurusamy3 2017Mesenchymal Stem Cells - Isolation, Characterization and Applications1000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.