Aims: The traditionally used biological markers for alcoholism include a wide range of sensitivity and specificity as single tests VSports手机版. This study focuses on the combination of established laboratory parameters with new meaningful biomarkers to advance the significance regarding alcohol dependence. .

Design: We analyzed blood samples from alcohol-dependent patients (n=177) compared with a control group (n=181) V体育安卓版. In the statistical calculation we included carbohydrate-deficient transferrin (CDT), mean corpuscular erythrocyte volume (MCV), gamma-glutamyltransferase (GGT), total plasma homocysteine, and folate. .

Results: None of the examined biomarkers reached sensitivity above 90% while all markers showed a good specificity. Combinations of different markers led to a significant elevation in sensitivity. Best values for men were achieved by using a combination of MCV, CDT, GGT, homocysteine and folate in different weightings (sensitivity: 98. 6%, specificity: 86. 4%). For women, similar results were yielded by combining MCV and CDT (sensitivity: 94 V体育ios版. 1%, specificity: 96%). The addition of homocysteine and folate in different weightings did not result in further enhancement. .

Conclusions: Gender-specific clusters including MCV, CDT, GGT, homocysteine and folate led to an increase in sensitivity compared to single laboratory markers VSports最新版本. This is a reliable help to identify patients with regular heavy drinking in clinical practice which might prevent further complications. .