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. 2005 Aug 19;309(5738):1256-9.
doi: 10.1126/science.1112521.

"V体育安卓版" Mitogenic influence of human R-spondin1 on the intestinal epithelium

Kyung-Ah Kim  1 , Makoto Kakitani, Jingsong Zhao, Takeshi Oshima, Tom Tang, Minke Binnerts, Yi Liu, Bryan Boyle, Emily Park, Peter Emtage, Walter D Funk, Kazuma Tomizuka
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"V体育ios版" Mitogenic influence of human R-spondin1 on the intestinal epithelium

Kyung-Ah Kim et al. Science. .

Abstract (V体育2025版)

Several described growth factors influence the proliferation and regeneration of the intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-spondin1, with potent and specific proliferative effects on intestinal crypt cells VSports手机版. Human R-spondin1 (hRSpo1) is a thrombospondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in various tissues. Upon injection into mice, the protein induced rapid onset of crypt cell proliferation involving beta-catenin stabilization, possibly by a process that is distinct from the canonical Wnt-mediated signaling pathway. The protein also displayed efficacy in a model of chemotherapy-induced intestinal mucositis and may have therapeutic application in gastrointestinal diseases. .

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