SRX1369077: Patients_Before_IPI1 ILLUMINA (Illumina MiSeq) run: 4. 7M spots, 2 V体育ios版. 7G bases, 1. 5Gb downloads.
Design: Culture-independent 16S rRNA gene sequencing approachSubmitted by: (INRA)Study: Anticancer immunotherapy by CTLA4 blockade relies on the gut microbiotaPRJNA299112 • SRP065109 • All experiments • All runsshow Abstracthide AbstractBlockade of CTLA4 by ipilimumab often results in immune-related adverse events atsites that are exposed to commensal microorganisms, mostly the gut. Patients treated withipilimumab develop antibodies to components of the enteric flora, suggesting that suchimmune reactions may contribute to colitis VSports最新版本. Therefore, addressing the role of gut microbiota inthe immunomodulatory effects of CTLA4 blockade is crucial for the future development ofimmune checkpoint blockers in oncology. Sample: SAMN04193694 • SRS1127214 • All experiments • All runsOrganism: human gut metagenomeLibrary: Name: Microbiota_Patients_Before_IPIInstrument: Illumina MiSeqStrategy: WGASource: METAGENOMICSelection: PCRLayout: PAIREDSpot descriptor: 1 forward251 reverseRuns: 1 run, 4. 7M spots, 2. 7G bases, 1. 5GbRun# of Spots# of BasesSizePublishedSRR27684544,662,4102. 7G1. 5Gb2015-11-12.