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Review
. 2022 Jul 13;14(14):2872.
doi: 10.3390/nu14142872.

"VSports app下载" The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept

Itai Sharon  1   2 , Narciso Martín Quijada  3   4 , Edoardo Pasolli  5   6 , Marco Fabbrini  7   8 , Francesco Vitali  9 , Valeria Agamennone  10 , Andreas Dötsch  11 , Evelyne Selberherr  3 , José Horacio Grau  12   13 , Martin Meixner  12 , Karsten Liere  12 , Danilo Ercolini  5   6 , Carlotta de Filippo  9 , Giovanna Caderni  14 , Patrizia Brigidi  8 , Silvia Turroni  7
Affiliations
Review

The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept

Itai Sharon et al. Nutrients. .

Abstract

The core microbiome, which refers to a set of consistent microbial features across populations, is of major interest in microbiome research and has been addressed by numerous studies. Understanding the core microbiome can help identify elements that lead to dysbiosis, and lead to treatments for microbiome-related health states. However, defining the core microbiome is a complex task at several levels. In this review, we consider the current state of core human microbiome research. We consider the knowledge that has been gained, the factors limiting our ability to achieve a reliable description of the core human microbiome, and the fields most likely to improve that ability. DNA sequencing technologies and the methods for analyzing metagenomics and amplicon data will most likely facilitate higher accuracy and resolution in describing the microbiome. However, more effort should be invested in characterizing the microbiome's interactions with its human host, including the immune system and nutrition. Other components of this holobiontic system should also be emphasized, such as fungi, protists, lower eukaryotes, viruses, and phages VSports手机版. Most importantly, a collaborative effort of experts in microbiology, nutrition, immunology, medicine, systems biology, bioinformatics, and machine learning is probably required to identify the traits of the core human microbiome. .

Keywords: NGS sequencing; core microbiome; diet; eukaryotes; gut; healthy microbiome; immune system; omics; prokaryotes; virome V体育安卓版. .

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Conflict of interest statement

The authors declare no conflict of interest.

Figures (V体育安卓版)

Figure 1
Figure 1
Community profiling of nine cohorts: HMP phases 1 (n = 138), 2 (n = 91), and 3 (n = 42); healthy individuals from Denmark (n = 64); individuals with IBD from Spain (n = 16); hunter-gatherers and traditional agriculturalists (n = 19); gorillas (n = 15); mice (n = 141); and chickens (n = 121). (a) The fraction of samples that contain each species, for species detected in at least 70% of the samples in at least one cohort (a total of 107 species). Refer to Supplementary Table S3 for a complete list of all the detected species in all cohorts. (b) The first two components of an unweighted UniFrac-based MDS analysis considering all samples. (c) The number of species detected in at least 90% of the samples of each cohort. Only one species (F. prausnitzii) was detected in 90% or more of the samples across all healthy human Western (n = 4) and all human (n = 6) datasets. (d) The number of pathways detected in >90% of the samples in all healthy Western human datasets (n = 4); all human datasets (n = 6); human and gorilla datasets (n = 7); human, gorilla, and mouse datasets (n = 8); and all datasets, including chickens (n = 9). See also Supplementary Tables S4 and S5.
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