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Clinical Trial
. 1993 Sep;23(9):540-5.
doi: 10.1111/j.1365-2362.1993.tb00963.x.

Effect of IgM-enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti-endotoxin antibodies in bone marrow transplantation

S K Jackson  1 , J Parton, R A Barnes, C H Poynton, C Fegan
Affiliations
Clinical Trial

Effect of IgM-enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti-endotoxin antibodies in bone marrow transplantation

S K Jackson et al. Eur J Clin Invest. 1993 Sep.

Abstract

Endotoxin was measured in over 1000 plasma samples from bone marrow transplant patients in a randomized trial of the IgM-enriched intravenous immunoglobulin (IVIG) Pentaglobin. Peak endotoxaemia was significantly reduced (P = 0. 02) in patients receiving Pentaglobin and 70% of all pyrexias of unknown origin were associated with endotoxaemia. Gut mucosal damage, assessed by lactulose/mannitol ratios, was significantly associated (P = 0. 02) with endotoxaemia. Specific IgM antibody to endotoxin core-glycolipid was significantly raised (P < 0 VSports手机版. 01) in patients receiving the IVIG, and the IgM fraction of Pentaglobin was found to contain most of the anti-endotoxin antibody activity of the IVIG. These results suggest a role for IgM-enriched IVIG as a prophylactic agent for the reduction of endotoxaemia and its consequences in bone marrow transplant patients. .

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