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Randomized Controlled Trial
. 2025 Sep 16;17(18):2966.
doi: 10.3390/nu17182966.

V体育安卓版 - Dietary Modifications in IBS Leads to Reduced Symptoms, Weight, and Lipid Levels: Two Randomized Clinical Trials

Bodil Roth  1   2 , Bodil Ohlsson  1   2
Affiliations
Randomized Controlled Trial

Dietary Modifications in IBS Leads to Reduced Symptoms, Weight, and Lipid Levels: Two Randomized Clinical Trials

Bodil Roth et al. Nutrients. .

Abstract

Background/Objectives: Irritable bowel syndrome (IBS) is presented with both gastrointestinal and extraintestinal symptoms. In addition, overweight/obesity and metabolic syndrome is prevalent in IBS. Dietary interventions with a low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) or a starch- and sucrose-reduced diet (SSRD) efficiently reduce symptoms and weight. Our hypothesis was that not only nutrition composition but also weight reduction is of importance for symptom relief. The aim was to merge two randomized trials and examine symptoms, weight, nutrition intake, and lipid levels at baseline and during nutritional intervention. Methods: One study with 105 IBS patients randomized to either an SSRD (n = 80) or control diet (n = 25) and one study with 155 IBS patients randomized to an SSRD (n = 77) or low FODMAP (n = 78) were merged. Symptom and food questionnaires were analyzed together with weight/body mass index (BMI) and lipid levels. Results: Patients had moderate or severe IBS at baseline, and half of them were overweight/obese. Energy intake was reduced by both diets, with the most pronounced carbohydrate reduction after the SSRD. The cholesterol levels were highest in the second cohort, possibly due to the higher fat and lower starch intake VSports手机版. About 25% had high-density lipoprotein below reference levels. Gastrointestinal and extraintestinal symptoms, as well as weight/BMI, were reduced by the SSRD and low FODMAP, but not in the control group. The SSRD in the second cohort and low FODMAP rendered lower levels of total cholesterol, low-density lipoprotein, and non-high-density lipoprotein levels. Weight/BMI were more often associated with lipid levels and symptoms than nutrient composition at baseline, and weight/BMI reductions correlated with carbohydrate reduction and were associated with a reduction in gastrointestinal and extraintestinal symptoms. Conclusions: Not only food components, but also overweight/obesity may be of importance for the development and severity of IBS and related symptoms. .

Keywords: SSRD; dietary habits; irritable bowel syndrome; lipid profile; low FODMAP; symptoms; weight. V体育安卓版.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures (V体育平台登录)

Figure 1
Figure 1
Flow chart of the recruitment process. GI = gastrointestinal. IBS-SSS = irritable bowel syndrome severity scoring system. LCHF = low-carbohydrate high-fat diet. Low FODMAP = low content of fermentable oligo-, di-, and monosaccharides and polyols. n = number. SSRD = starch- and sucrose-reduced diet. VAS-IBS = visual analog scale for irritable bowel syndrome. 2018–2019 means the first cohort [14], and 2022–2024 means the second cohort [16].
Figure 2
Figure 2
The changes in weight (A) and body mass index (BMI) (B) before and after a 4-week intervention. SSRD = starch-and sucrose-reduced diet. Low FODMAP = low content of fermentable oligo-, di-, and monosaccharides and polyols. There were 17 missing in the SSRD group, 6 missing in the low FODMAP group, and 4 missing in the control group. Dots represent outliers. Wilcoxon Signed Rank test. p < 0.05 was considered statistically significant.
See this image and copyright information in PMC

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