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Randomized Controlled Trial
. 2025 Aug 15;15(1):29975.
doi: 10.1038/s41598-025-15953-2.

The impacts of Crocin on serum cytokines concentrations in participants with metabolic syndrome: a double-blind randomized clinical trial study

Razie Rezaiee  1 , Hamideh Ghazizadeh  1   2   3 , Susan Darroudi  1 , Roshanak Ghaffarian Zirak  1 , Mohadese Rohban  1 , Marziyeh Eidi  1 , Irandokht Nikbakht Jam  1 , Ali Asghar Mahmoudi  1 , Farzin Hadizadeh  4 , Malihe Aghasizadeh  5   6 , Abbas Mohtashamian  5   7 , Majid Ghayour-Mobarhan  8   9
Affiliations
Randomized Controlled Trial

The impacts of Crocin on serum cytokines concentrations in participants with metabolic syndrome: a double-blind randomized clinical trial study

"V体育官网" Razie Rezaiee et al. Sci Rep. .

VSports注册入口 - Abstract

The aim of this study was to investigate the effect of Crocin on the inflammatory cytokines profile in patients with Metabolic syndrome (Mets). Twenty-eight patients with Mets (15 cases and 13 controls) were randomly selected by the International Diabetes Federation (IDF) definite criteria in a double-blind randomized clinical trial. Participants were divided into two treatment groups, a group received 15 mg of Crocin (two tablets per day), and the other one received a placebo for eight weeks. Inflammatory and growth factors were measured using a sandwich chemiluminescence assay, before and after treatment. Our results indicated that inflammatory factors including IL-2, IL-10, VEGF and INF γ, were significantly reduced (P < 0. 05) in patients with Mets after Crocin treatment. Moreover, no significant difference was detected among the other biochemical factors (lipid profile and FBG) between two groups. The results showed the exclusive impact of Crocin on the reduction of serum inflammatory cytokines. Crocin has the potential to be further investigated as a useful therapeutic factor in inflammatory diseases VSports手机版. Clinical trial registration number: IRCT2013080514279N1, Registration date: 01/02/2015. .

Keywords: Cytokines concentration; Metabolic syndrome; Randomized double-blind clinical trial; Saffron V体育安卓版. .

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V体育ios版 - Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests V体育ios版. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Mashhad University of Medical Sciences. Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent to publish: Not applicable.

V体育ios版 - Figures

Fig. 1
Fig. 1
CONSORT 2010 Flow Diagram.
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