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. 2025 Mar 7:13:1519246.
doi: 10.3389/fped.2025.1519246. eCollection 2025.

V体育2025版 - Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis

Mallory A Perry-Eaddy  1   2   3 , Walter Faig  4 , Martha A Q Curley  5   6   7 , Scott L Weiss  8   9
Affiliations

Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis

V体育安卓版 - Mallory A Perry-Eaddy et al. Front Pediatr. .

Abstract

Objective: New functional morbidity is common in critically ill children who survive sepsis; yet, the underlying biological mechanisms, particularly the impact of inflammation, remain unknown. We sought to test the hypothesis that increased levels of inflammatory biomarkers during the acute phase of pediatric sepsis are associated with new functional morbidity at hospital discharge VSports手机版. .

Methods: We conducted a post hoc secondary analysis of the MitoPSe clinical study, including N = 119 critically ill children who survived sepsis V体育安卓版. Data collected included demographic and clinical variables and 31 inflammatory biomarkers collected at three distinct timepoints (within days 1-2 of PICU admission, days 3-5, and days 8-14). The primary outcome was new functional morbidity, defined as at least a one-point increase in the pediatric overall performance category from baseline to hospital discharge. .

Results: New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < . 001) at all three timepoints. However, after adjusting for differences in chronic comorbid conditions, hospital length of stay, number of organ dysfunctions, and severity of illness, absolute biomarker levels, and trajectories were not significantly different between patients with or without new functional morbidity at hospital discharge V体育ios版. .

Conclusions: In this sample of critically ill children treated for sepsis, increased inflammatory biomarker levels and the trajectory of change during the acute phase of pediatric sepsis were not independently associated with new functional morbidity at hospital discharge. Inflammatory biomarker levels likely reflect illness severity and other clinical variables associated with illness. However, these biomarkers may still be useful in identifying patients at risk of developing functional morbidity, despite the lack of causation within this study. VSports最新版本.

Keywords: biomarkers; functional status; inflammation; pediatric intensive care unit; sepsis. V体育平台登录.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Inflammatory biomarker trajectories associated with new functional morbidity at PICU discharge over time. Unadjusted trajectories of log-transformed mean inflammatory biomarker levels [IL-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, RANTES (CCL5), and IL-2r] that are associated with new functional morbidity across three distinct timepoints, (1) days 1–2 of PICU admission, (2) days 3–5, and (3) between days 8 and 14. With the exception of RANTES, each biomarker followed similar trajectories with elevated biomarker levels in those who develop new morbidity at PICU discharge compared to those who do not. After adjusting for clinical variables, inflammatory biomarkers no longer remained associated with new functional morbidity.
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