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. 2022 Dec 30:15:6923-6930.
doi: 10.2147/JIR.S393506. eCollection 2022.

Clinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction

Xiaojuan Li  1 , Tiewei Li  1 , Geng Dong  1 , Yulei Wei  1 , Zhe Xu  1 , Junmei Yang  1
Affiliations

Clinical Value of Serum Interleukin-18 in Neonatal Sepsis Diagnosis and Mortality Prediction

"VSports app下载" Xiaojuan Li et al. J Inflamm Res. .

Abstract

Purpose: Previous studies have demonstrated that interleukin-18 (IL-18) levels were elevated in adult patients with sepsis. However, its role in neonatal sepsis remains unknown VSports手机版. The current research was conducted to assess the clinical value of serum IL-18 level as a candidate biomarker in neonatal sepsis diagnosis and prediction of mortality. .

Patients and methods: From July 2022 to September 2022, we prospectively enrolled 91 septic neonates and 31 non-sepsis neonates in the intensive care unit of neonates at Henan Children's Hospital in Zhengzhou, China. Neonatal peripheral blood serum was collected at admission and levels of serum IL-18 were assessed. Employing multivariate logistic regression analysis, the evaluation of the potential of IL-18 as an independent biomarker for sepsis was executed. Furthermore, employing the receiver operating characteristic (ROC) curve analysis, the diagnostic value of IL-18 in sepsis and the ability of IL-18 in predicting the mortality of neonatal sepsis was measured. The statistical package SPSS 24 V体育安卓版. 0 was employed to conduct all statistical analyses. .

Results: Serum IL-18 levels in neonates in the sepsis group were elevated compared to the control group, reaching the highest levels in the non-survival sepsis group (P < 0. 001). Correlation analysis exhibited a positive relationship between IL-18 levels and age, body temperature, respiratory rate, and C-reactive protein levels. IL-18 was identified as an independent biomarker in identifying sepsis (OR = 4. 747, 95% CI 1. 493-15. 092, P = 0. 008) by multiple logistic regression. ROC curve analysis exhibited that IL-18 was good in identifying neonatal sepsis (area under curve (AUC) = 0. 77, 95% CI = 0. 68-0. 85, P < 0. 001) and predicting neonatal mortality (AUC = 0. 80, 95% CI = 0. 63-0. 96, P = 0. 003) V体育ios版. .

Conclusion: IL-18 was a potential biomarker for identifying neonatal sepsis and neonatal mortality prediction. VSports最新版本.

Keywords: interleukin-18; mortality; neonatal sepsis. V体育平台登录.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

"VSports" Figures

Figure 1
Figure 1
ROC curve of IL-18 in neonatal sepsis diagnosis and mortality prediction. (A) The ROC curve for IL-18 in neonatal sepsis diagnosis; (B) The ROC curve for IL-18 in predicting neonatal mortality prediction.
Figure 2
Figure 2
Distribution of neonates in high or low IL-18 groups.
See this image and copyright information in PMC

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