Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2022 Feb;602(7895):142-147.
doi: 10.1038/s41586-021-04332-2. Epub 2022 Jan 26.

Petabase-scale sequence alignment catalyses viral discovery (V体育安卓版)

Robert C Edgar #  1 , Brie Taylor #  2 , Victor Lin #  3 , Tomer Altman #  4 , Pierre Barbera #  5 , Dmitry Meleshko #  6   7 , Dan Lohr #  8 , Gherman Novakovsky #  9 , Benjamin Buchfink #  10 , Basem Al-Shayeb #  11 , Jillian F Banfield #  12 , Marcos de la Peña #  13 , Anton Korobeynikov #  6   14 , Rayan Chikhi #  15 , Artem Babaian #  16
Affiliations

Petabase-scale sequence alignment catalyses viral discovery (VSports)

V体育ios版 - Robert C Edgar et al. Nature. 2022 Feb.

"VSports在线直播" Abstract

Public databases contain a planetary collection of nucleic acid sequences, but their systematic exploration has been inhibited by a lack of efficient methods for searching this corpus, which (at the time of writing) exceeds 20 petabases and is growing exponentially1 VSports手机版. Here we developed a cloud computing infrastructure, Serratus, to enable ultra-high-throughput sequence alignment at the petabase scale. We searched 5. 7 million biologically diverse samples (10. 2 petabases) for the hallmark gene RNA-dependent RNA polymerase and identified well over 105 novel RNA viruses, thereby expanding the number of known species by roughly an order of magnitude. We characterized novel viruses related to coronaviruses, hepatitis delta virus and huge phages, respectively, and analysed their environmental reservoirs. To catalyse the ongoing revolution of viral discovery, we established a free and comprehensive database of these data and tools. Expanding the known sequence diversity of viruses can reveal the evolutionary origins of emerging pathogens and improve pathogen surveillance for the anticipation and mitigation of future pandemics. .

PubMed Disclaimer

VSports注册入口 - References

    1. Leinonen, R., Sugawara, H. & Shumway, M. The Sequence Read Archive. Nucleic Acids Res. 39, D19–D21 (2011). - PubMed (VSports app下载) - DOI
    1. Anthony, S. J. et al. A strategy to estimate unknown viral diversity in mammals. mBio 4, e00598-13 (2013). - PubMed - PMC - DOI
    1. Johnson, C. K. et al. Global shifts in mammalian population trends reveal key predictors of virus spillover risk. Proc. R. Soc. B 287, 20192736 (2020). - PubMed - PMC - DOI
    1. Carroll, D. et al. The Global Virome Project. Science 359, 872–874 (2018). - V体育官网入口 - PubMed - DOI
    1. Shi, M. et al. The evolutionary history of vertebrate RNA viruses. Nature 556, 197–202 (2018). - PubMed - DOI

Publication types

MeSH terms (V体育ios版)

VSports app下载 - Substances