V体育ios版 - Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2020 Sep 15:883:173358.
doi: 10.1016/j.ejphar.2020.173358. Epub 2020 Jul 22.

Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-κB signaling and NLRP3 inflammasome

Yonger Chen  1 , Yingyu Lu  2 , Chaoying Pei  1 , Jian Liang  3 , Ping Ding  2 , Shuxian Chen  4 , Shao-Zhen Hou  5
Affiliations

VSports app下载 - Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-κB signaling and NLRP3 inflammasome

Yonger Chen et al. Eur J Pharmacol. .

"V体育官网" Abstract

Recently, it has reported that many inflammatory bowel disease (IBD) patients were contracted secondary liver injury. Monotropein (MON), an iridoid glycoside, is demonstrated to possess protective effects on acute colitis mice due to its anti-inflammatory activities. However, it was remained unknown whether MON could inhibit secondary liver injury caused by IBD. The aim of the present study was to investigate the protective roles and mechanisms of MON on secondary liver injury in chronic colitis mice model. In this study, 2% Dextran sodium sulfate (DSS) was used to induce mice model of chronic colitis. The results showed that MON attenuated DSS-induced hepatic pathological damage, liver parameters, infiltration of macrophages and cytokines levels. Furthermore, we found that MON attenuated liver injury through suppressing the activation of the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway and down-regulating the activity of NLRP3 (NOD-, LRR- and pyrin domain-containing 3) inflammasome VSports手机版. All the data indicated that MON may be an effective therapeutic reagent to attenuate secondary liver injury induced by chronic colitis. .

Keywords: DSS; Monotropein; NLRP3; Secondary liver injury; TLR4/NF-κB V体育安卓版. .

PubMed Disclaimer

MeSH terms