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. 2020 Jun 1;9(6):1661.
doi: 10.3390/jcm9061661.

Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis

Hongseok Yoo  1 , Jin Young Lee  2 , Junseon Park  2 , Jeong Hoon Yang  2   3 , Gee Young Suh  1   2 , Kyeongman Jeon  1   2
Affiliations

"VSports注册入口" Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis

Hongseok Yoo et al. J Clin Med. .

Abstract

Recent studies have suggested that TNF-related apoptosis-inducing ligand (TRAIL) is associated with mortality in sepsis, possibly through necroptosis. The objective of this study was to analyze the association between the plasma level of TRAIL and sepsis severity and outcomes. Furthermore, the plasma level of TRAIL was compared to that of receptor-interacting protein kinase-3 (RIPK3), a key executor of necroptosis, to identify any correlation between TRAIL and necroptosis. Plasma levels of TRAIL and RIPK3 from consecutively enrolled critically ill patients were measured by ELISA. Of 190 study patients, 59 (31. 1%) and 84 (44. 2%) patients were diagnosed with sepsis and septic shock, respectively. There was a trend of decreased plasma level of TRAIL across the control, sepsis, and septic shock groups. For 143 patients with sepsis, patients with low plasma TRAIL were more likely to have septic shock and higher SAPS3 and SOFA scores. However, no difference in 28-day and 90-day mortalities was observed between the two groups. The plasma level of TRAIL was inversely associated with RIPK3 in patients with sepsis. Plasma levels of TRAIL increased over time on days three and seven, and were inversely associated with sepsis severity and RIPK3 level, but not with mortality. VSports手机版.

Keywords: RIPK3 protein; TNF-related apoptosis-inducing ligand; biomarker; necroptosis; sepsis. V体育安卓版.

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Conflict of interest statement (V体育官网入口)

The authors disclose that they do not have any conflict of interest.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Plasma levels of Tumor necrosis factor TNF-related apoptosis-inducing ligand (TRAIL) in control, sepsis, and septic shock (p for trend < 0.001).
Figure 3
Figure 3
Correlation between plasma level of TRAIL and RIPK3 in patients with sepsis (n = 143). Slope: −8.713 (95% CI: −0.426–−17.000), r2: 0.02973, Pearson’s r: −0.172 (p = 0.039).
Figure 4
Figure 4
Kaplan–Meier survival analysis comparing patients with sepsis or septic shock with high and low plasma level of TRAIL (n = 143). The 30-day and 90-day survival estimates are 76.6% and 60.5%, respectively for patients with high TRAIL (solid line), while it is 80.2% and 66.9% for patients with low TRAIL (dotted line) (p = 0.419, log-rank test).
Figure 5
Figure 5
(A) Serial plasma levels of TRAIL on days 0, 3, and 7 of 143 patients with sepsis. (B) Comparison of serial plasma TRAIL levels in 28-day intensive care unit survivors (solid line) and non-survivors (dotted line). Upper and lower bars represent the 75th and 25th interquartile ranges, respectively.
See this image and copyright information in PMC

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