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. 2020 Sep 2;11(5):1300-1313.
doi: 10.1080/19490976.2020.1748261. Epub 2020 Apr 24.

"V体育官网入口" Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health

Baolei Jia  1   2 , Dongbin Park  2 , Yoonsoo Hahn  2 , Che Ok Jeon  2
Affiliations

Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health

Baolei Jia et al. Gut Microbes. .

Abstract (VSports最新版本)

Bile acid metabolism by the gut microbiome exerts both beneficial and harmful effects on host health. Microbial bile salt hydrolases (BSHs), which initiate bile acid metabolism, exhibit both positive and negative effects on host physiology. In this study, 5,790 BSH homologs were collected and classified into seven clusters based on a sequence similarity network. Next, the abundance and distribution of BSH in 380 metagenomes from healthy participants were analyzed. It was observed that different clusters occupied diverse ecological niches in the human microbiome and that the clusters with signal peptides were relatively abundant in the gut. Then, the association between BSH clusters and 12 human diseases was analyzed by comparing the abundances of BSH genes in patients (n = 1,605) and healthy controls (n = 1,540). The analysis identified a significant association between BSH gene abundance and 10 human diseases, including gastrointestinal diseases, obesity, type 2 diabetes, liver diseases, cardiovascular diseases, and neurological diseases VSports手机版. The associations were further validated by separate cohorts with inflammatory bowel diseases and colorectal cancer. These large-scale studies of enzyme sequences combined with metagenomic data provide a reproducible assessment of the association between gut BSHs and human diseases. This information can contribute to future diagnostic and therapeutic applications of BSH-active bacteria for improving human health. .

Keywords: Gut microbiome; bile acids; bile salt hydrolase; human health; metagenomic cohorts V体育安卓版. .

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V体育官网入口 - Figures

Figure 1.
Figure 1.
Protein sequence similarity network (SSN) of bile salt hydrolases (BSHs).
Figure 2.
Figure 2.
The abundance and distribution of the bile salt hydrolases (BSHs) in the 380 microbiomes from healthy human participants.
Figure 3.
Figure 3.
Bubble plot of the association between the abundance of bile salt hydrolases (BSHs) and host diseases.
Figure 4.
Figure 4.
Validation of the association between the abundance of bile salt hydrolases (BSHs) in the gut and the disease conditions using independent study populations.
See this image and copyright information in PMC

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