Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Randomized Controlled Trial
. 2020 Feb 6;382(6):503-513.
doi: 10.1056/NEJMoa1911793. Epub 2020 Jan 29.

"VSports注册入口" Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

Harry J de Koning  1 , Carlijn M van der Aalst  1 , Pim A de Jong  1 , Ernst T Scholten  1 , Kristiaan Nackaerts  1 , Marjolein A Heuvelmans  1 , Jan-Willem J Lammers  1 , Carla Weenink  1 , Uraujh Yousaf-Khan  1 , Nanda Horeweg  1 , Susan van 't Westeinde  1 , Mathias Prokop  1 , Willem P Mali  1 , Firdaus A A Mohamed Hoesein  1 , Peter M A van Ooijen  1 , Joachim G J V Aerts  1 , Michael A den Bakker  1 , Erik Thunnissen  1 , Johny Verschakelen  1 , Rozemarijn Vliegenthart  1 , Joan E Walter  1 , Kevin Ten Haaf  1 , Harry J M Groen  1 , Matthijs Oudkerk  1
Affiliations
Randomized Controlled Trial

Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

Harry J de Koning et al. N Engl J Med. .

Abstract

Background: There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers. VSports手机版.

Methods: A total of 13,195 men (primary analysis) and 2594 women (subgroup analyses) between the ages of 50 and 74 were randomly assigned to undergo CT screening at T0 (baseline), year 1, year 3, and year 5. 5 or no screening. We obtained data on cancer diagnosis and the date and cause of death through linkages with national registries in the Netherlands and Belgium, and a review committee confirmed lung cancer as the cause of death when possible V体育安卓版. A minimum follow-up of 10 years until December 31, 2015, was completed for all participants. .

Results: Among men, the average adherence to CT screening was 90. 0%. On average, 9. 2% of the screened participants underwent at least one additional CT scan (initially indeterminate). The overall referral rate for suspicious nodules was 2. 1%. At 10 years of follow-up, the incidence of lung cancer was 5. 58 cases per 1000 person-years in the screening group and 4. 91 cases per 1000 person-years in the control group; lung-cancer mortality was 2. 50 deaths per 1000 person-years and 3. 30 deaths per 1000 person-years, respectively. The cumulative rate ratio for death from lung cancer at 10 years was 0. 76 (95% confidence interval [CI], 0. 61 to 0 V体育ios版. 94; P = 0. 01) in the screening group as compared with the control group, similar to the values at years 8 and 9. Among women, the rate ratio was 0. 67 (95% CI, 0. 38 to 1. 14) at 10 years of follow-up, with values of 0. 41 to 0. 52 in years 7 through 9. .

Conclusions: In this trial involving high-risk persons, lung-cancer mortality was significantly lower among those who underwent volume CT screening than among those who underwent no screening. There were low rates of follow-up procedures for results suggestive of lung cancer. (Funded by the Netherlands Organization of Health Research and Development and others; NELSON Netherlands Trial Register number, NL580 VSports最新版本. ). .

PubMed Disclaimer

"VSports注册入口" Comment in

V体育安卓版 - Publication types

VSports最新版本 - MeSH terms