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. 2019 Aug:120:22-27.
doi: 10.1016/j.cyto.2019.04.003. Epub 2019 Apr 16.

Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers

Magdalena Mierzchala-Pasierb  1 , Malgorzata Krzystek-Korpacka  2 , Patrycja Lesnik  3 , Barbara Adamik  4 , Sylwia Placzkowska  5 , Pawel Serek  6 , Andrzej Gamian  7 , Malgorzata Lipinska-Gediga  8
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V体育官网入口 - Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers

"V体育官网入口" Magdalena Mierzchala-Pasierb et al. Cytokine. 2019 Aug.

Abstract (V体育官网)

Purpose: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and a syndrome shaped by pathogen and host factors with characteristic that evolve over time. The study was conducted to evaluate the prognostic and discriminative value of IL-18 assessment in comparison to PCT, CRP, WBC in early stage of sepsis and septic shock VSports手机版. .

Methods: An observational and prospective study was conducted in the group of 40 ICU patients with diagnosis of sepsis or septic shock, serum PCT, IL-18, CRP and WBC measurements were performed on admission, and on the 2nd, 3rd and 5th therapy day. The level of IL-18 was determined with commercially available test according to manufacturer's protocol. V体育安卓版.

Results: There were no statistically significant differences in IL-18 levels in survivors vs non-survivors and in sepsis vs septic shock subgroups the IL-18 levels were statistically significant in the course of the study except for the 5th day V体育ios版. .

Conclusion: The PCT, CRP and WBC levels revealed no significant differences between any analyzed subgroups in all time points during study VSports最新版本. According to our results the IL-18 is a biomarker better differentiating sepsis and septic shock status than PCT, CRP and WBC but with no prognostic impact. .

Keywords: Biomarker; Interleukin 18; Sepsis; Septic shock. V体育平台登录.

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