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Meta-Analysis
. 2018 Dec;97(49):e13407.
doi: 10.1097/MD.0000000000013407.

"VSports app下载" The higher serum endocan levels may be a risk factor for the onset of cardiovascular disease: A meta-analysis

Tianming Zhao  1 , Yao Kecheng  2 , Xuelei Zhao  3 , Xuehua Hu  1 , Jing Zhu  1 , Yingnan Wang  1 , Jixiang Ni  1
Affiliations
Meta-Analysis

"VSports在线直播" The higher serum endocan levels may be a risk factor for the onset of cardiovascular disease: A meta-analysis

Tianming Zhao et al. Medicine (Baltimore). 2018 Dec.

Abstract

Objective: Endothelial dysfunction was widely regarded as the initial lesion in the multifactorial pathogenesis of cardiovascular disease (CVD). Serum endocan, a novel endothelial dysfunction biochemical marker, is involved in the development of CVD. Here, we fulfilled a meta-analysis to evaluate the association between CVD and serum endocan levels VSports手机版. .

Method: The relevant published literature was searched through large literature databases, including PubMed, Embase, Cochrane Library, SinoMed, and Web of Science, up to June 1, 2018. The data were extracted from the studies. Stata software was used to perform a meta-analysis. V体育安卓版.

Result: Fifteen original studies with a total of 1839 patients and 1258 controls fulfilled the inclusion criteria and were included in the study dataset. Meta-analysis showed that the levels of serum endocan in patients with hypertension, coronary artery disease, and coronary slow flow were higher than those in the control group. The pooled standardized mean differences and 95% confidence intervals of endocan concentrations in those 3 groups were 0. 53 [0. 19-0. 86], P < . 01; 0. 99 [0. 51-1. 39], P < . 01; and 0 V体育ios版. 62 [0. 45-0. 78], P < . 01, respectively. Further analysis showed that the level of serum endocan in hypertension patients with coronary artery disease was higher than that in patients with hypertension (0. 61 [0. 30-0. 92], P < . 01). Sensitivity analysis and subgroup analysis were use to confirm the above results. .

Conclusions: In this meta-analysis, we further confirmed that serum endocan level was significantly increased in the CVD population VSports最新版本. The high serum endocan level may be one of the risk factors for CVD. .

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Conflict of interest statement

Conflict of interest: The author (s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures (V体育官网)

Figure 1
Figure 1
Flow chart of the identification and inclusion of articles.
Figure 2
Figure 2
The forest plot for endocan levels in CVD patients: (A) hypertension and normotension, (B) coronary artery disease and non-coronary artery disease, (C) coronary slow flow and normal coronary flow, and (D) hypertension with coronary artery disease and hypertension. CVD = cardiovascular disease.
Figure 3
Figure 3
Sensitivity analysis for endocan levels in CVD patients. CVD = cardiovascular disease.
Figure 4
Figure 4
Begg's funnel plot for endocan levels in CVD patients. CVD = cardiovascular disease.
See this image and copyright information in PMC

References (V体育2025版)

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