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Review
. 2018 Oct 1;39(5):760-802.
doi: 10.1210/er.2018-00064.

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Nadia Bougarne  1   2 , Basiel Weyers  1   2 , Sofie J Desmet  1   2 , Julie Deckers  3   4 , David W Ray  5 , Bart Staels  6   7   8   9 , Karolien De Bosscher  1   2
Affiliations
Free article
Review

Molecular Actions of PPARα in Lipid Metabolism and Inflammation

Nadia Bougarne et al. Endocr Rev. .
Free article

Abstract

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials VSports手机版. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications. .

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