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Clinical Trial
. 2017:2017:5969657.
doi: 10.1155/2017/5969657. Epub 2017 Dec 20.

Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection

JiaWan Wang  1 , AnShi Wu  1 , Yan Wu  1
Affiliations
Clinical Trial

V体育官网 - Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection

JiaWan Wang et al. Biomed Res Int. 2017.

Abstract

Background: Shedding of the endothelial glycocalyx layer (EGL) is known to occur during major surgery, but its degradation associated with minimally invasive video-assisted thoracoscopy (VATS) remains unclear VSports手机版. We investigated if serum biomarkers of EGL disruption were elevated during VATS lobectomy, and whether the urinary trypsin inhibitor (UTI) ulinastatin exerted a protective effect during this procedure. .

Materials and methods: Sixty ASA II-III lung cancer patients undergoing elective VATS lobectomy were divided equally into UTI and control groups. UTI group patients received intravenous UTI during surgery. Serum levels of syndecan-1 and heparan sulfate were examined before (T0) and at the end of surgery (T1) V体育安卓版. Serum albumin and hemoglobin were measured before surgery (BOD) and on the first postoperative day (POD1). .

Results: In control group, syndecan-1 levels were significantly elevated at T1 compared with T0 (3 V体育ios版. 77 ± 3. 15 versus 4. 28 ± 3. 30, P = 0. 022⁎) and increased even more significantly in patients whose surgery lasted >3 h (3. 28 ± 2. 84 versus 4. 31 ± 3. 39, P = 0. 003⁎⁎). Serum albumin levels on POD1 were significantly lower in control group compared with UTI group (32. 63 ± 4. 57 versus 35. 76 ± 2. 99, P = 0. 031⁎). .

Conclusion: EGL degradation occurs following VATS lobectomy. UTI can alleviate this shedding, thus helping preserve normal vascular permeability VSports最新版本. .

Trail registration: This trial is registered with ChiCTR-IOC-17010416 (January 13, 2017). V体育平台登录.

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Figures

Figure 1
Figure 1
Syndecan-1 levels were significantly elevated in the control group at T1 compared with T0 (3.77 ± 3.15 versus 4.28 ± 3.30, P = 0.022∗), whereas the increase was not significant in the UTI group (3.98 ± 3.04 versus 4.24 ± 3.12, P = 0.160). The procedure lasted >3 h in 15 patients in the control group and 19 in the UTI group (long-duration cases). Syndecan-1 levels were elevated more significantly at T1 compared with T0 among long-duration cases (3.28 ± 2.84 versus 4.31 ± 3.39, P = 0.003∗∗), whereas the increase was still not significant in the equivalent UTI group (4.17 ± 3.29 versus 4.51 ± 3.41, P = 0.138).
Figure 2
Figure 2
There was no obvious variation in HS levels in either group overall or among long-duration cases.
Figure 3
Figure 3
Serum albumin levels were significantly lower in the control compared with the UTI long-duration group at POD1 (32.63 ± 4.57 versus 35.76 ± 2.99, P = 0.031∗), while there was no significant difference in HGB levels between the two groups.
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References

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