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Review
. 2016 Jun 2;165(6):1332-1345.
doi: 10.1016/j.cell.2016.05.041.

"V体育平台登录" From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Ara Koh  1 , Filipe De Vadder  1 , Petia Kovatcheva-Datchary  1 , Fredrik Bäckhed  2
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Review

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites (VSports最新版本)

Ara Koh et al. Cell. .
Free article

Abstract

A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis. A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host VSports手机版. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease. .

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