Population-level analysis of gut microbiome variation (V体育平台登录)

Gwen Falony¹, Marie Joossens², Sara Vieira-Silva¹, Jun Wang¹, Youssef Darzi², Karoline Faust², Alexander Kurilshikov³, Marc Jan Bonder⁴, Mireia Valles-Colomer¹, Doris Vandeputte², Raul Y Tito², Samuel Chaffron², Leen Rymenans², Chloë Verspecht¹, Lise De Sutter², Gipsi Lima-Mendez¹, Kevin D'hoe², Karl Jonckheere⁵, Daniel Homola⁵, Roberto Garcia⁵, Ettje F Tigchelaar⁶, Linda Eeckhaudt⁵, Jingyuan Fu⁷, Liesbet Henckaerts⁸, Alexandra Zhernakova⁶, Cisca Wijmenga⁴, Jeroen Raes⁹

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¹ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium.
² KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.
³ Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. Novosibirsk State University, Novosibirsk, Russia.
⁴ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands.
⁵ VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.
⁶ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands. Top Institute Food and Nutrition, Wageningen, Netherlands.
⁷ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands. University of Groningen, University Medical Center Groningen, Department of Pediatrics, 9700 RB Groningen, Netherlands.
⁸ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. KU Leuven-University Hospitals Leuven, Department of General Internal Medicine, Leuven, Belgium.
⁹ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium. jeroen.raes@qiuluzeuv.cn.

PMID: 27126039
DOI: 10.1126/science.aad3503

Population-level analysis of gut microbiome variation

Gwen Falony et al. Science. 2016.

. 2016 Apr 29;352(6285):560-4.

doi: 10.1126/science.aad3503. Epub 2016 Apr 28.

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Affiliations

¹ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium.
² KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.
³ Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. Novosibirsk State University, Novosibirsk, Russia.
⁴ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands.
⁵ VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium.
⁶ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands. Top Institute Food and Nutrition, Wageningen, Netherlands.
⁷ University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, Netherlands. University of Groningen, University Medical Center Groningen, Department of Pediatrics, 9700 RB Groningen, Netherlands.
⁸ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. KU Leuven-University Hospitals Leuven, Department of General Internal Medicine, Leuven, Belgium.
⁹ KU Leuven-University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium. VIB, Center for the Biology of Disease, Leuven, Belgium. Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Microbiology Unit, Brussels, Belgium. jeroen.raes@qiuluzeuv.cn.

PMID: 27126039
DOI: 10.1126/science.aad3503

Abstract

Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate VSports手机版. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design. .

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Population-level analysis of gut microbiome variation (V体育平台登录)

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Population-level analysis of gut microbiome variation

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