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. 2016 Jun;100(3):363-9.
doi: 10.1016/j.yexmp.2015.12.002. Epub 2015 Dec 3.

"VSports" New insights on the palate, lung, and nasal epithelium clone (PLUNC) proteins: Based on molecular and functional analysis of its homolog of YH1/SPLUNC1

Hui Liu  1 , Xiangning Zhang  2 , Jingjing Wu  2 , Samuel W French  3 , Zhiwei He  4
Affiliations

New insights on the palate, lung, and nasal epithelium clone (PLUNC) proteins: Based on molecular and functional analysis of its homolog of YH1/SPLUNC1

VSports最新版本 - Hui Liu et al. Exp Mol Pathol. 2016 Jun.

Abstract

The palate, lung, and nasal epithelium clone (PLUNC) proteins are intricate immune molecules and arisen questions from them are still unresolved. In order to identify the role of PLUNC family proteins, we had analyzed its homolog protein YH1/SPLUNC1, which highly expresses in nontumor nasopharyngeal epithelium while expresses weakly in nasopharyngeal carcinoma (NPC) tissues. It is found that YH1/SPLUNC1 protein expression level was higher in chronic normal nasopharynx inflammatory cells compared to NPC tissue cells. An approach to produce active YH1/SPLUNC1 protein had been established and recombinant YH1/SPLUNC1 protein could bind to all four Gram-positive and four Gram-negative bacteria we tested, and triggered the aggregation of those bacteria VSports手机版. Interestingly, YH1/SPLUNC1 protein has antimicrobial activity, and it can directly kill Escherichia coli and Acinetobacter haemolyticus. The microorganism cell showed morphological changes in cell wall such as cell damage and cytoplasmic leakage after exposure to YH1/SPLUNC1 protein, indicating that YH1/SPLUNC1 directly killed the microorganisms by cell wall permeabilization. All these results indicated that YH1/SPLUNC1 might be an important antimicrobial protein involved in innate immunity defense. .

Keywords: Antimicrobial activity; Innate immunity; Nasopharyngeal carcinoma (NPC); Recombinant YH1/SPLUNC1 protein; The palate lung and nasal epithelium clone (PLUNC) V体育安卓版. .

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