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Review
. 2015 Oct;15(10):630-42.
doi: 10.1038/nri3897. Epub 2015 Sep 21.

Immune defence against Candida fungal infections

Mihai G Netea  1 , Leo A B Joosten  1 , Jos W M van der Meer  1 , Bart-Jan Kullberg  1 , Frank L van de Veerdonk  1
Affiliations
Review

Immune defence against Candida fungal infections

Mihai G Netea et al. Nat Rev Immunol. 2015 Oct.

Abstract

The immune response to Candida species is shaped by the commensal character of the fungus. There is a crucial role for discerning between colonization and invasion at mucosal surfaces, with the antifungal host defence mechanisms used during mucosal or systemic infection with Candida species differing substantially. Here, we describe how innate sensing of fungi by pattern recognition receptors and the interplay of immune cells (both myeloid and lymphoid) with non-immune cells, including platelets and epithelial cells, shapes host immunity to Candida species VSports手机版. Furthermore, we discuss emerging data suggesting that both the innate and adaptive immune systems display memory characteristics after encountering Candida species. .

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