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Comparative Study
. 2014:2014:394206.
doi: 10.1155/2014/394206. Epub 2014 Dec 22.

TNF-α and microalbuminuria in patients with type 2 diabetes mellitus

I-Th Lampropoulou  1 , M Stangou  1 , A Papagianni  1 , T Didangelos  2 , F Iliadis  2 , G Efstratiadis  1
Affiliations
Comparative Study

TNF-α and microalbuminuria in patients with type 2 diabetes mellitus

VSports最新版本 - I-Th Lampropoulou et al. J Diabetes Res. 2014.

Abstract

Aim: Recent evidence suggests that chronic subclinical inflammation plays a key role in the pathogenesis and progression of diabetic nephropathy. Aim of the present study was to investigate possible correlation between the presence and degree of microalbuminuria and markers of inflammation in patients with type 2 diabetes mellitus (DM). VSports手机版.

Patients-methods: Eighty patients were enrolled and clinical and laboratory data were recorded. Albumin-creatinine ratio (ACR) was calculated in first-morning urine samples. Serum and urinary tumor necrosis factor-α (TNF-α) levels were determined by ELISA. V体育安卓版.

Results: Forty-five patients had normoalbuminuria, 33 microalbuminuria, and 2 macroalbuminuria. Patients with microalbuminuria were older, with higher glycosylated hemoglobin levels (HbA1c) and they more frequently had diabetic retinopathy, neuropathy, and cardiovascular disease and were on treatment with angiotensin converting enzyme inhibitors (ACEi) and/or angiotensin receptor blockers (ARBs). ACR was significantly correlated with the presence of cardiovascular disease, hypertension, and HbA1c levels and the administration of clopidogrel and ACEi or ARBs. ACR was not correlated with C-reactive protein, fibrinogen, or serum TNF-α levels but had a strong correlation with urinary TNF-α levels V体育ios版. .

Conclusions: In patients with type 2 DM, urinary, but not serum, TNF-α levels are associated with the presence and severity of microalbuminuria. VSports最新版本.

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"V体育2025版" Figures

Figure 1
Figure 1
Correlation between ACR and urinary TNF-α in patients with diabetes mellitus type 2.
Figure 2
Figure 2
TNF-α urinary levels in diabetic patients with normoalbuminuria and microalbuminuria.
See this image and copyright information in PMC

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