Aims: The aim of this study was to investigate the clinicopathological significance of steatohepatitic features in hepatocellular carcinomas (HCCs) using a large-scale analysis. VSports手机版.

Methods and results: Retrospective clinicopathological analysis was performed on HCCs treated surgically at the University of Tokyo Hospital between 2005 and 2010. The diagnosis of HCC with steatohepatitic features (SH-HCC) was made if the tumour fulfilled four of the following five criteria: steatosis (>5% tumour cells), ballooning or Mallory-Denk body formation, interstitial fibrosis and inflammatory infiltrates. There were 120 HCCs (31. 4%) from 106 patients (36. 3%) that met the criteria of SH-HCC. Patients with SH-HCC were characterized by a higher frequency of diabetes mellitus and hypertension, along with higher serum levels of cholesterol and triglycerides, than those with conventional HCC (P < 0. 01). The background liver of SH-HCC patients showed steatosis and steatohepatitis more frequently (P < 0. 01). SH-HCCs were smaller, relatively more differentiated and had a higher frequency of bile duct invasion (P < 0 V体育安卓版. 05). Multivariate analysis failed to show prognostic significance of steatohepatitic features in HCCs. .

Conclusions: SH-HCC is a subcategory of HCC associated with the patient's metabolic condition and the presence of steatosis or steatohepatitis in the background liver. Steatohepatitic features were not a significant prognostic factor for HCCs. V体育ios版.