"VSports注册入口" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2013 Nov 15;45(22):1049-59.
doi: 10.1152/physiolgenomics.00116.2013. Epub 2013 Sep 17.

miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Affiliations

miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma (V体育安卓版)

VSports手机版 - Paige E Bennett et al. Physiol Genomics. .

Abstract

Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer VSports手机版. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed. .

Keywords: BRAF; MITF; miR-137; miR-18b; miR-214. V体育安卓版.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Complexity of microRNA (miRNA, also miR) regulation in melanoma. Examples of various ways that miRNAs regulate expression of gene(s) involved in cancer hallmark characteristics. A: miR-137 is an example of how a single miRNA can regulate many genes, enabling melanoma cells to acquire multiple hallmark functions (6, 53). B: micropthalmia-associated transcription factor (MITF) is an example of one gene regulated by multiple miRNAs to fine tune the control of gene expression (6, 28, 30, 78). C: ApoE signaling pathway is an example of multiple miRNAs regulating multiple genes within one signaling pathway in order to maximize inhibition of this pathway (69).

References

    1. Alla V, Kowtharapu BS, Engelmann D, Emmrich S, Schmitz U, Steder M, Putzer BM. E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry. Cell Cycle 11: 3067–3078, 2012. - PMC - PubMed
    1. Arcaroli JJ, Quackenbush KS, Powell RW, Pitts TM, Spreafico A, Varella-Garcia M, Bemis L, Tan AC, Reinemann JM, Touban BM, Dasari A, Eckhardt SG, Messersmith WA. Common PIK3CA mutants and a novel 3′ UTR mutation are associated with increased sensitivity to saracatinib. Clin Cancer Res 18: 2704–2714, 2012. - "V体育官网入口" PMC - PubMed
    1. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, Tait JF, Tewari M. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108: 5003–5008, 2011. - PMC - PubMed
    1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, function. Cell 116: 281–297, 2004. - PubMed
    1. Bell RE, Levy C. The three M's: melanoma, microphthalmia-associated transcription factor and microRNA. Pigm Cell Melanoma Res 24: 1088–1106, 2011. - PubMed

Publication types

MeSH terms

LinkOut - more resources