miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma
- PMID: 24046283
- PMCID: PMC4596730
- DOI: "V体育安卓版" 10.1152/physiolgenomics.00116.2013
miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma (V体育安卓版)
Abstract
Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer VSports手机版. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed. .
Keywords: BRAF; MITF; miR-137; miR-18b; miR-214. V体育安卓版.
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