Background: Measurement of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) has recently become more popular as a means of assessing oxidative stress in the human body VSports手机版. The aim of this study is to compare the levels of urine 8-OHdG in patients with type 2 diabetes with and without nephropathy and to evaluate its role as a biochemical marker for distinguishing these patients from healthy and patients without complications. .

Methods: For this purpose, 52 patients with type 2 diabetes mellitus (32 with nephropathy (DMN), 20 without nephropathy (DM)) and 20 healthy control subjects (C) were included in this study V体育安卓版. The urine concentrations of 8-OHdG were measured by modified LC-MS/MS method and compared with the first morning voiding urine albumin/creatinine ratio (UACR) and HbA1c values of the same patients. .

Results: The concentrations of urine 8-OHdG in DMN and DM patients were higher than those of the control subjects (3. 47 ± 0. 94, 2. 92 ± 1. 73, 2. 1 ± 0. 93 nmol/mol creatinine, respectively). But there was no statistical difference between DMN and DM (p = 0. 115). There is significant correlation between urinary 8-OHdG and UACR (r = 0. 501, p < 0. 001). According to ROC analysis, the AUC value of HbA1c was higher than the value of the AUC of 8-OHdG (0. 882 and 0. 771, respectively). V体育ios版.

Conclusions: This study shows that the urine 8-OHdG levels increase in diabetic patients. However, urinary 8-OHdG is not a useful clinical marker, compared with UACR, to predict the development of diabetic nephropathy in diabetic patients. VSports最新版本.