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Review
. 2012 Sep 1;88(6):543-52.
doi: 10.1016/j.brainresbull.2012.05.017. Epub 2012 Jun 9.

Genes associated with autism spectrum disorder

Xiaohong Li  1 , Hua Zou, W Ted Brown
Affiliations
Review

Genes associated with autism spectrum disorder

Xiaohong Li et al. Brain Res Bull. .

Abstract

Autism spectrum disorder (ASD) is a heterogeneous grouping of neurodevelopmental disorders characterized by impairment in social interaction, verbal communication and repetitive/stereotypic behaviors. Much evidence suggests that ASD is multifactorial with a strong genetic basis, but the underlying mechanisms are far from clear VSports手机版. Recent advances in genetic technologies are beginning to shed light on possible etiologies of ASD. This review discusses current evidence for several widely studied candidate ASD genes, as well as various rare genes that supports their relationship to the etiology of ASD. The majority of the data are based on molecular, cytogenetic, linkage and association studies of autistic subjects, but newer methods, including whole-exome sequencing, are also beginning to make significant contributions to our understanding of autism. .

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