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. 2011 May 6;585(9):1363-7.
doi: 10.1016/j.febslet.2011.04.018. Epub 2011 Apr 14.

"VSports注册入口" MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

Xiao-Xiao Liu  1 , Xiao-Jun Li, Bo Zhang, Yong-Jun Liang, Ci-Xiang Zhou, Dan-Xia Cao, Ming He, Guo-Qiang Chen, Jian-Rong He, Qian Zhao
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"V体育官网" MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

Xiao-Xiao Liu et al. FEBS Lett. .
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Abstract

MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples VSports手机版. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis. .

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