"V体育官网" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2010 Apr-Jun;4(2):199-203.
doi: 10.4161/cam.4.2.10943. Epub 2010 Apr 14.

Snail: More than EMT (VSports手机版)

Yadi Wu  1 , Binhua P Zhou
Affiliations
Review

Snail: More than EMT

Yadi Wu et al. Cell Adh Migr. 2010 Apr-Jun.

Abstract

Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies VSports手机版. .

PubMed Disclaimer

Figures

Figure 1
Figure 1
Snail displays a broad spectrum of biological functions in the epithelial-mesenchymal transition (EMT), cell survival, immune regulation, tumor recurrence and stem cell biology.
See this image and copyright information in PMC

References

    1. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol. 2002;3:155–166. - PubMed
    1. Peinado H, Ballestar E, Esteller M, Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol. 2004;24:306–319. - PMC - PubMed
    1. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7:415–428. - PubMed
    1. Rowe RG, Li XY, Hu Y, Saunders TL, Virtanen I, Garcia de Herreros A, et al. Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol. 2009;184:399–408. - "V体育平台登录" PMC - PubMed
    1. Franci C, Takkunen M, Dave N, Alameda F, Gomez S, Rodriguez R, et al. Expression of Snail protein in tumor-stroma interface. Oncogene. 2006;25:5134–5144. - "V体育官网" PubMed