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. 2009 Apr;49(4):719-24.
doi: 10.1111/j.1537-2995.2008.02025.x. Epub 2008 Dec 15.

"VSports app下载" JAL (RH48) blood group antigen: serologic observations

Christine Lomas-Francis  1 , Denden Alcantara, Connie Westhoff, Joan Uehlinger, Marilia Valvasori, Lillian Castilho, Marion E Reid
Affiliations

VSports手机版 - JAL (RH48) blood group antigen: serologic observations

Christine Lomas-Francis et al. Transfusion. 2009 Apr.

Abstract

Background: JAL (RH48) is a low-prevalence antigen in the Rh blood group system and anti-JAL has caused hemolytic disease of the newborn VSports手机版. JAL is associated with either a haplotype carrying depressed C and e antigens or one carrying depressed c and e antigens. Blood samples from JAL+ people were tested, published serologic findings were confirmed, serologic studies were extended to include expression of other Rh antigens, and the antibody specificities produced by three sensitized JAL+ probands are reported. .

Study design and methods: Red blood cell (RBC) samples from 17 (12 probands) JAL+ persons were tested by hemagglutination using standard methods V体育安卓版. .

Results: RBCs from both the Caucasian JAL+ probands had the (C)(e) haplotype and weakened C, e, hr(B), and hr(S) antigens V体育ios版. JAL+ samples from black persons had the (c)(e) haplotype and expressed weakened c, e, f, V, VS, hr(B), and hr(S) antigens. Plasma from three sensitized c+e+ JAL+ probands contained alloanti-c, alloanti-e, or alloantibody of apparent anti-Rh17 specificity. This study shows that this alloanti-Rh17-like antibody recognizes the high-prevalence antigen antithetical to JAL that has been named CEST. .

Conclusions: The presence of the JAL antigen has a quantitative (weakening) effect on the expression of C, e, hr(B), and hr(S) antigens in Caucasian persons and of c, e, f, V, VS, hr(B), and hr(S) antigens in people of black African ancestry. A qualitative effect also was demonstrated by the presence of alloanti-c or alloanti-e in the plasma of two transfused c+e+ patients and by an antibody (anti-CEST) that recognizes the high-prevalence antigen antithetical to JAL VSports最新版本. .

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Figures

Fig. 1
Fig. 1
Family pedigree for Sample 13. The arrow indicates the proband. The JAL status of II-1 is predicted from DNA test results.
See this image and copyright information in PMC

References

    1. Reid ME, Lomas-Francis C. Blood group antigen factsbook. 2. San Diego: Academic Press; 2004.
    1. Westhoff CM. The structure and function of the Rh antigen complex. Semin Hematol. 2007;44:42–50. - VSports手机版 - PMC - PubMed
    1. Moulds JJ, Case J, Anderson TD, Cooper ES. The first example of allo-anti-c produced by a c-positive individual. Recent advances in haematology, immunology and blood transfusion: Proceedings of the Plenary Sessions of the Joint Meeting of the 19th Congress of the International Society of Haematology and the 17th Congress of the International Society of Blood Transfusion; Budapest. August 1982; New York: John Wiley & Sons; 1983.
    1. Faas BH, Ligthart PC, Lomas-Francis C, Overbeeke MA, von dem Borne AE, van der Schoot CE. Involvement of Gly96 in the formation of the Rh26 epitope. Transfusion. 1997;37:1123–30. - PubMed
    1. Huestis DW, Catino ML, Busch S. A “new” Rh antibody (anti-Rh 26) which detects a factor usually accompanying hr’. Transfusion. 1964;4:414–8. - PubMed

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