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. 2008 Nov;153(5):646-50.
doi: 10.1016/j.jpeds.2008.04.062. Epub 2008 Jun 9.

Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome

Robert J Shulman  1 , Michelle N Eakin, Danita I Czyzewski, Monica Jarrett, Ching-Nan Ou
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Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome

Robert J Shulman et al. J Pediatr. 2008 Nov.

Abstract

Objectives: To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling VSports手机版. .

Study design: GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern. V体育安卓版.

Results: Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0. 59 +/- 0. 50 vs 0. 36 +/- 0. 26, respectively; mean +/- SD; P < . 001) as was colonic permeability (1. 01 +/- 0. 67 vs 0. 81 +/- 0. 43, respectively; P < . 05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65. 5 +/- 75. 4 microg/g stool vs 43. 2 +/- 39. 4, respectively; P < . 01). Fecal calprotectin concentration correlated with pain interference with activities (P = . 01, r(2) = 0 V体育ios版. 36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form. .

Conclusions: Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities VSports最新版本. .

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References

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