Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2007 Aug 10;317(5839):807-10.
doi: 10.1126/science.1144090.

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Andrew S Brack  1 , Michael J Conboy, Sudeep Roy, Mark Lee, Calvin J Kuo, Charles Keller, Thomas A Rando
Affiliations

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Andrew S Brack et al. Science. .

Abstract

The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate and that this conversion is mediated by factors in the systemic environment of the old animals. We also show that this lineage conversion is associated with an activation of the canonical Wnt signaling pathway in aged myogenic progenitors and can be suppressed by Wnt inhibitors VSports手机版. Furthermore, components of serum from aged mice that bind to the Frizzled family of proteins, which are Wnt receptors, may account for the elevated Wnt signaling in aged cells. These results indicate that the Wnt signaling pathway may play a critical role in tissue-specific stem cell aging and an increase in tissue fibrosis with age. .

PubMed Disclaimer

Publication types (V体育2025版)

MeSH terms (VSports)