Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Comparative Study
. 2007 May;149(5):260-4.
doi: 10.1016/j.trsl.2006.12.003.

Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate

Guoqing Hou  1 , Robert Dick, Chunhua Zeng, George J Brewer
Affiliations
Comparative Study

Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate (V体育ios版)

Guoqing Hou et al. Transl Res. 2007 May.

Abstract

Tetrathiomolybdate (TM) is an anticopper drug under development for treating Wilson's disease. Its mechanism of action involves forming a tight tripartite complex in the blood with serum albumin and available copper. When available copper levels are lowered in animals with TM, strong antiangiogenic and antitumor effects are observed. Similarly, TM has excellent efficacy in animal models of fibrotic, inflammatory, and autoimmune diseases, and it protects against heart damage from doxorubicin (DXR) and liver damage from acetaminophen, carbon tetrachloride, and concanavalin A. Tetrathiotungstate (TT) also forms a similar tripartite complex in the blood and has similar effects to TM on copper. In this article, whether TT had similar antitumor effects, and similar effects in protecting the heart against DXR toxicity, as TM was evaluated VSports手机版. It was found that the 2 drugs were comparable in their effects when doses were used that lowered copper availability to the same extent. .

PubMed Disclaimer

Publication types

MeSH terms

"VSports注册入口" LinkOut - more resources