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. 2007 Mar 21;13(11):1666-71.
doi: 10.3748/wjg.v13.i11.1666.

"VSports" Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

Ichiro Hirata  1 , Shingo Yasumoto, Ken Toshina, Takuya Inoue, Takashi Nishikawa, Naoko Murano, Mitsuyuki Murano, Fang-Yu Wang, Ken-ichi Katsu
Affiliations

Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis

Ichiro Hirata (V体育2025版) et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the effect of pyrrolidine dithio-carbamate (PDTC; an NF-kappaB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. VSports手机版.

Methods: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated group I (low-dose group), and DSS+PDTC-treated group II (high-dose group) V体育安卓版. In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-kappaB and inflammatory cytokines (IL-1beta and TNF-alpha) in tissue were measured. .

Results: The DSS+PDTC-treated group II exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-kappaB level and IL-1beta and TNF-alpha levels were significantly lower in DSS+PDTC-treated group II V体育ios版. .

Conclusion: These findings suggest that PDTC is useful for the treatment of ulcerative colitis VSports最新版本. .

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Figures

Figure 1
Figure 1
Method of DSS colitis model and administration of PDTC.
Figure 2
Figure 2
The effect of PDTC on clinical indices (DAI). aP < 0.05, bP < 0.01, vs control group.
Figure 3
Figure 3
Comparison of length of colon in different groups.
Figure 4
Figure 4
The effect of PDTC on length of colon. aP < 0.05, P = NS, vs control group. NS: not significant.
Figure 5
Figure 5
Histological findings of distal colon in mouse. A: normal; B: control; C: PDTC-treated groupI (low dose); D: PDTC-treated group II (high dose).
Figure 6
Figure 6
The effect of PDTC on histological disease score. P = NS vs control group. NS: not significant.
Figure 7
Figure 7
The effect of PDTC on NF-κ concentration. aP < 0.05, bP < 0.01, vs control group.
Figure 8
Figure 8
A: The effect of PDTC on IL-1β cytokine concentration. aP < 0.05, P = NS, vs control group. NS: not significant; B: The effect of PDTC on TNF-α cytokine concentration. aP < 0.05 vs control group.
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References (VSports手机版)

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    1. Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergran DJ. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci. 1993;38:1722–1734. - PubMed

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