Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Clinical Trial
. 2007 Apr;166(4):311-8.
doi: 10.1007/s00431-007-0419-x. Epub 2007 Feb 8.

V体育2025版 - The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers

Jobst Henker  1 , Martin Laass, Boris M Blokhin, Yuriy K Bolbot, Vitaliy G Maydannik, Martina Elze, Corinna Wolff, Jürgen Schulze
Affiliations
Clinical Trial

The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers

"V体育官网" Jobst Henker et al. Eur J Pediatr. 2007 Apr.

Abstract

In most cases, acute diarrhoea will become self-limiting during the first few days after onset. For young children, however, health risks may develop when the disease lasts longer than 3 days VSports手机版. The purpose of the present trial was to determine whether the stool frequency of infants and toddlers suffering from acute diarrhoea could be normalised more quickly by administering the probiotic Escherichia coli Nissle 1917 (EcN) solution than by administering a placebo. The safety of EcN were also assessed. A total of 113 children (aged 2-47 months) with acute diarrhoea (> three watery or loose stools in 24 h) were randomised to either a group receiving the probiotic EcN suspension (n = 55) or a group receiving the placebo suspension (n = 58) in a confirmative, double-blind clinical trial. Depending on the age of patients, 1-3 ml per day of verum suspension (10(8) viable EcN cells per millilitre) or placebo were administered orally. The causes of the diarrhoea were viral rather than bacterial, but they were mainly unspecific infections. The median onset of treatment response (reduction of daily stool frequency to

PubMed Disclaimer

V体育官网入口 - Figures

Fig. 1
Fig. 1
Study design. *Final visit Duration of treatment, which was until ascertainment of response, 10 days at maximum
Fig. 2
Fig. 2
Diagram of participant flow
Fig. 3
Fig. 3
Time-to-response curves: Kaplan-Meier analysis (ITT analysis)
Fig. 4
Fig. 4
Response rates among the patients receiving the EcN solution (n = 55) and placebo (n = 58) during the course of the study
See this image and copyright information in PMC

VSports - References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0928-8244(03)00368-7', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0928-8244(03)00368-7'}, {'type': 'PubMed', 'value': '15039098', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15039098/'}]}
    2. Altenhoefer A, Oswald S, Sonnenborn U, Enders C, Schulze J, Hacker J, Oelschlaeger TA (2004) The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens. FEMS Immunol Med Microbiol 40:223–229 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0923-2508(02)00007-4', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0923-2508(02)00007-4'}, {'type': 'PubMed', 'value': '12576161', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12576161/'}]}
    2. Blum-Oehler G, Oswald S, Eiteljörge K, Sonnenborn U, Schulze J, Kruis W, Hacker J (2003) Development of strain-specific PCR reactions for the detection of the probiotic Escherichia coli strain Nissle 1917 in fecal samples. Res Microbiol 154:59–66 - "VSports在线直播" PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1046/j.1365-3083.2002.01005.x', 'is_inner': False, 'url': 'https://doi.org/10.1046/j.1365-3083.2002.01005.x'}, {'type': 'PubMed', 'value': '11896937', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11896937/'}]}
    2. Cukrowska B, Lodinova-Zadnikova R, Enders C, Sonnenborn U, Schulze J, Tlaskalova-Hogenova H (2002) Specific proliferative and antibody response of premature infants to intestinal colonization with nonpathogenic probiotic E. coli strain Nissle 1917. Scand J Immunol 55:204–209 - VSports app下载 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1136/bmj.324.7350.1361', 'is_inner': False, 'url': 'https://doi.org/10.1136/bmj.324.7350.1361'}, {'type': 'PMC', 'value': 'PMC115209', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC115209/'}, {'type': 'PubMed', 'value': '12052801', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12052801/'}]}
    2. D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ (2002) Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 324:1361–1366 - PMC - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1128/JB.184.21.5912-5925.2002', 'is_inner': False, 'url': 'VSports app下载 - https://doi.org/10.1128/jb.184.21.5912-5925.2002'}, {'type': 'PMC', 'value': 'PMC135379', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC135379/'}, {'type': 'PubMed', 'value': '12374825', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12374825/'}]}
    2. Grozdanov L, Zähringer U, Blum-Oehler G, Brade L, Henne A, Knirel YA, Schombel U, Schulze J, Sonnenborn U, Gottschalk G, Hacker J, Rietschel ET, Dobrindt U (2002) A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917. J Bacteriol 184:5912–5925 - V体育安卓版 - PMC - PubMed

Substances (VSports最新版本)