Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

Review
. 2006 Oct:21:307-15.
doi: 10.1152/physiol.00021.2006.

Selenoproteins and their impact on human health through diverse physiological pathways

Behzad Moghadaszadeh  1 , Alan H Beggs
Affiliations
Review

"VSports在线直播" Selenoproteins and their impact on human health through diverse physiological pathways

Behzad Moghadaszadeh et al. Physiology (Bethesda). 2006 Oct.

Abstract

In the last few decades, the importance of selenium in human health has been the subject of numerous studies. It is believed that the physiological effects of selenium occur mainly through the function of selenoproteins, which incorporate selenium in the form of one or more selenocysteine residues. Recent advances in understanding the complex regulation of selenoprotein synthesis and functional characterization of several members of the selenoprotein family have contributed to an improved comprehension of the role(s) of selenium in human health and the great diversity of physiological pathways influenced by this trace element VSports手机版. .

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Schematic showing cis- and trans-acting elements required for selenocysteine incorporation into selenoproteins
FIGURE 2
FIGURE 2. Biochemical and physiological roles of selenoproteins
Major known activities and roles for the 25 selenoproteins identified in humans are indicated. Many proteins likely have multiple other functions not indicated here. Involvement in oxidoreduction reactions is a unifying feature of this protein family; however, there is great diversity in tissue distribution and physiological pathways where these reactions occur. The biochemical activities and/or physiological roles of more than half these proteins remain unknown. CNS, central nervous system.
FIGURE 3
FIGURE 3. Selenoprotein P knockout mouse phenotypes
Interactions between genotype and environmental factors are evident in Sepp1 knockout mice, whose severe phenotype can be ameliorated by nutritional supplementation with a high selenium diet.
See this image and copyright information in PMC

References

    1. Allmang C, Krol A. Selenoprotein synthesis: UGA does not end the story. Biochimie. In press. - "V体育2025版" PubMed
    1. Beck MA, Esworthy RS, Ho YS, Chu FF. Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J. 1998;12:1143–1149. - "V体育官网入口" PubMed
    1. Becker K, Gromer S, Schirmer RH, Muller S. Thioredoxin reductase as a pathophysiological factor and drug target. Eur J Biochem. 2000;267:6118–6125. - "V体育安卓版" PubMed
    1. Beckett GJ, Arthur JR. Selenium and endocrine systems. J Endocrinol. 2005;184:455–465. - PubMed
    1. Behne D, Hilmert H, Scheid S, Gessner H, Elger W. Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochim Biophys Acta. 1988;966:12–21. - V体育官网 - PubMed

Publication types

LinkOut - more resources