Background & aims: An association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists. Familial clustering of IR may support a genetic predisposition to NAFLD or cryptogenic cirrhosis (CC) VSports手机版. .

Methods: Patients with NAFLD (n = 20) and healthy controls (n = 20) matched for age, sex, and body mass index with at least 4 living relatives and 2 generations of lineage participated in a familial aggregation study V体育安卓版. A medical history was obtained from each subject and confirmed with first-degree family members. .

Results: NAFLD patients were more likely to have cirrhosis (odds ratio [OR] = 12. 0), cardiac disease (OR, 3. 0), hyperlipidemia (OR, 12. 1), diabetes mellitus (DM) (OR, 9. 1), renal stones (OR, 4. 1), and arthritis (OR, 6. 1). IR (P = . 042) (the primary dependent variable) and DM (P = . 013) were noted in their first-degree relatives. A trend for familial clustering of NAFLD or CC (P = . 059) with a maternal linkage for disease expression also may exist. Cholelithiasis (P = . 047), presumed NAFLD and/or CC (P = . 049), and a trend toward IR (P = . 07) were noted in the mothers, but not the fathers, of patients with NAFLD. An increased risk of DM (OR, 4. 2; 95% confidence interval, 1. 26-18. 7; P = . 013), IR (OR, 2. 86; 95% confidence interval, 1 V体育ios版. 02-9. 38; P = . 042), and smoking (OR, 3. 41; 95% confidence interval, 1. 43-9. 07; P = . 003) was observed in first-degree relatives of NAFLD patients. No significant survival difference was observed between family cohorts. .

Conclusions: Familial clustering and a potential maternal linkage for IR support a genetic predisposition for NAFLD. Alternatively, the presence of suppressor genes modifying the expression of IR in paternal lineage warrants further investigation VSports最新版本. .