Background: Obesity is an increasing health problem in developed countries, where the prevalence of Helicobacter pylori infection is decreasing. Recent studies suggested colonization of the stomach by H pylori might affect gastric expression of appetite- and satiety-related hormone and patients cured of H pylori infection gained weight. It was hypothesized that H pylori could be a contributing pathogenic factor in childhood and adult obesity VSports手机版. .

Methods: To determine whether H pylori infection is linked to obesity, a case-control study composed of 414 patients with morbid obesity (a body mass index [calculated as weight in kilograms divided by the square of height in meters] of > or = 35 with serious comorbidity or a body mass index of > or = 40) and 683 control subjects (a body mass index of <25) with a comparable socioeconomic status was conducted. Immunoglobulin G antibodies against H pylori were measured from frozen serum samples by an enzyme-linked immunosorbent assay. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI). V体育安卓版.

Results: The overall seropositivity was significantly lower in obese patients (181 [43 V体育ios版. 7%] of 414) than controls (410 [60. 0%] of 683) (OR, 0. 50; 95% CI, 0. 39-0. 65; P<. 001). Differences in the estimated risk of the presence of H pylori were more pronounced in younger age groups, with ORs of 0. 32 (95% CI, 0. 10-1. 00; P = . 05) in those aged 10 to 19 years, 0. 55 (95% CI, 0. 34-0. 89; P = . 01) in those aged 20 to 29 years, 0. 49 (95% CI, 0. 30-0. 80; P = . 007) in those aged 30 to 39 years, and 0. 58 (95% CI, 0. 33-1. 00; P = . 05) in those aged 40 years or older. .

Conclusions: Our data indicated an inverse relationship between morbid obesity and H pylori seropositivity. These findings raise the hypothesis that a lack of H pylori infection, especially during childhood, might enhance the risk of the development of morbid obesity VSports最新版本. .